Dene is rushed into the hospital having suffered with a sudden headache and doctors are forced to operate despite his brain scan being unlike anything that they have seen before. Helga hopes that the doctors will be able to stop her painful cluster headaches.

Simon and Alex have both been diagnosed with having brain tumours. Lisa is brought in for some sophisticated surgery to try to cure her epilepsy.

A patient faces being kept awake during brain surgery.

We follow 24-year-old Bradley, who must decide whether to undergo radical surgery.