Return of the series in which life-saving and life-changing operations involve split-second decisions. Sajid has a massive aneurysm. If it bursts, he will bleed to death.

Surgeons face a challenge as Susan's cancer spreads from her jaw to her eye and nose. Removing it will leave a significant hole in her face, needing complex reconstruction.

Syed's life hangs in the balance as his testicular cancer has spread into his heart. If the tumour dislodges, it could block prove fatal. Consultant urological surgeons undertake a radical plan with the monumental task of removing the tumour, along with help from the cardiac surgeons. In the thoracic theatres, surgeon prepares to operate on 77-year-old David. Last year, David underwent surgery in another hospital to remove cancer from his rib, but tests revealed that the disease is growing back. Renal surgeons prepare to perform a life-changing kidney transplant. Mark had his kidneys removed due to kidney disease, leaving him entirely reliant on dialysis to survive. His half-brother James voluntarily undergoes surgery to donate his kidney and give Mark his life back.